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Nitric oxide-sensitive guanylyl cyclase (EC 4.6.1.2) is a heterodimeric enzyme consisting of an alpha and a beta subunit. The enzyme converts GTP into the second messenger cGMP and plays a major role in the cardiovascular system as a receptor for nitric oxide.
The predicted 682-amino acid rat protein shares 27% identity with rat GCS-beta-1 (GUCY1B3). Unlike other guanylyl cyclases, GCS-beta-2 contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation / carboxymethylation. Northern blot analysis indicated that GCS-beta-2 is expressed at higher levels in rat kidney and liver, whereas GCS-beta-1 is preferentially expressed in lung and brain.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Guanylate Cyclase 1 Beta 2 (GUCY1b2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Guanylate Cyclase 1 Beta 2 (GUCY1b2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Guanylate Cyclase 1 Beta 2 (GUCY1b2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Guanylate Cyclase 1 Beta 2 (GUCY1b2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Guanylate Cyclase 1 Beta 2 (GUCY1b2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Guanylate Cyclase 1 Beta 2 (GUCY1b2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Guanylate Cyclase 1 Beta 2 (GUCY1b2) | ELISA Kit Customized Service Offer |
- "The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma."Biochem. Biophys. Res. Commun. 271:64-69(2000) [PubMed] [Europe PMC] [Abstract]
- "Assignment of GUCY1B2, the gene coding for the beta2 subunit of human guanylyl cyclase to chromosomal band 13q14.3 between markers D13S168 and D13S155."Genomics 55:126-127(1999) [PubMed] [Europe PMC] [Abstract]