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Trans-2,3-Enoyl Coenzyme A Reductase (TECR)

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TER; SC2; GPSN2; glycoprotein,synaptic 2; Very-long-chain enoyl-CoA reductase; Synaptic glycoprotein SC2

Trans-2,3-Enoyl Coenzyme A Reductase (TECR)
CCC H971
HGNC 4551
MGI 1915408
PubMed 21212097
RGD 620376
UniProt Q9NZ01
Wiki TECR
Microsomal long and very long chain fatty acid elongation uses malonyl-CoA as the 2-carbon donor and consists of 4 sequential reactions. TER catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA.
The deduced 308-amino acid protein contains 5 transmembrane domains. It shares 95% amino acid identity with mouse Ter and 34% identity with yeast Tsc13. Northern blot analysis detected a 1.2-kb transcript in all human and mouse tissues examined. Epitope-tagged TER colocalized predominantly with long chain fatty acid elongase (ELOVL6) in the endoplasmic reticulum of transfected Chinese hamster ovary cells. A small amount colocalized with GM130 (GOLGA2) in the Golgi.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trans-2,3-Enoyl Coenzyme A Reductase (TECR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trans-2,3-Enoyl Coenzyme A Reductase (TECR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trans-2,3-Enoyl Coenzyme A Reductase (TECR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trans-2,3-Enoyl Coenzyme A Reductase (TECR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trans-2,3-Enoyl Coenzyme A Reductase (TECR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trans-2,3-Enoyl Coenzyme A Reductase (TECR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trans-2,3-Enoyl Coenzyme A Reductase (TECR) ELISA Kit Customized Service Offer
  1. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade."J. Biol. Chem. 278:7335-7343(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  6. "ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis."Proc. Natl. Acad. Sci. U.S.A. 107:18439-18444(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of the N-terminal ubiquitin-like domain in human synaptic glycoprotein SC2."Submitted (MAR-2007) to the PDB data bank
  9. "Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13."Hum. Mol. Genet. 20:1285-1289(2011) [PubMed] [Europe PMC] [Abstract]