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G Protein Pathway Suppressor 2 (GPS2)

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AMF-1

G Protein Pathway Suppressor 2 (GPS2)
CCC H972
HGNC 4550
MGI 1891751
PubMed 11931768
RGD 1562746
UniProt Q13227
GPS2 encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression.
The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Pathway Suppressor 2 (GPS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Pathway Suppressor 2 (GPS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Pathway Suppressor 2 (GPS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Pathway Suppressor 2 (GPS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Pathway Suppressor 2 (GPS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Pathway Suppressor 2 (GPS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Pathway Suppressor 2 (GPS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Pathway Suppressor 2 (GPS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Pathway Suppressor 2 (GPS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Pathway Suppressor 2 (GPS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Pathway Suppressor 2 (GPS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Pathway Suppressor 2 (GPS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Pathway Suppressor 2 (GPS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Pathway Suppressor 2 (GPS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Pathway Suppressor 2 (GPS2) ELISA Kit Customized Service Offer
  1. "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells."Mol. Cell. Biol. 16:6698-6706(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]