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G Protein Pathway Suppressor 1 (GPS1)

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CSN1; COPS1; SGN1; COP9 signalosome complex subunit 1; Signalosome subunit 1; JAB1-containing signalosome subunit 1; Protein MFH

G Protein Pathway Suppressor 1 (GPS1)
CCC H973
HGNC 4549
MGI 2384801
PubMed 8943324
RGD 621532
UniProt Q13098
Wiki GPS1
GPS1 is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Sequence analysis revealed that the GPS1 gene encodes a 500-amino acid polypeptide that has striking similarity to the protein encoded by the Arabidopsis FUS6/COP11 gene. The FUS6/COP11 gene product is a negative regulator of light-mediated signal transduction that is known to be essential for normal development in plants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Pathway Suppressor 1 (GPS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Pathway Suppressor 1 (GPS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Pathway Suppressor 1 (GPS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Pathway Suppressor 1 (GPS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Pathway Suppressor 1 (GPS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Pathway Suppressor 1 (GPS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Pathway Suppressor 1 (GPS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Pathway Suppressor 1 (GPS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Pathway Suppressor 1 (GPS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Pathway Suppressor 1 (GPS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Pathway Suppressor 1 (GPS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Pathway Suppressor 1 (GPS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Pathway Suppressor 1 (GPS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Pathway Suppressor 1 (GPS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Pathway Suppressor 1 (GPS1) ELISA Kit Customized Service Offer
  1. "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells."Mol. Cell. Biol. 16:6698-6706(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits."FASEB J. 12:469-478(1998) [PubMed] [Europe PMC] [Abstract]
  6. "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system."EMBO J. 20:1630-1639(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain."J. Mol. Biol. 305:1-9(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome."Science 292:1382-1385(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1."J. Biol. Chem. 277:45759-45764(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage."Cell 113:357-367(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome."EMBO J. 22:1302-1312(2003) [PubMed] [Europe PMC] [Abstract]
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry."J. Proteome Res. 7:4914-4925(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]