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G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1)

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GASP; GASP1

G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1)
CCC H974
HGNC 24834
MGI 1917418
PubMed 16224249
RGD 621343
UniProt Q5JY77
Wiki GPRASP1
GPRASP1 encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes.
The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified.Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor Associated Sorting Protein 1 (GPRASP1) ELISA Kit Customized Service Offer
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  4. "Modulation of postendocytic sorting of G protein-coupled receptors."Science 297:615-620(2002) [PubMed] [Europe PMC] [Abstract]
  5. "A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)."J. Biol. Chem. 279:54291-54303(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]