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Golgi Reassembly Stacking Protein 2 (GORASP2)

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GOLPH6; GRASP55; GRS2; p59; Golgi phosphoprotein 6; Golgi reassembly-stacking protein of 55 kDa

Golgi Reassembly Stacking Protein 2 (GORASP2)
CCC H987
HGNC 17500
MGI 2135962
PubMed 22068051
RGD 619911
UniProt Q9H8Y8
Wiki GORASP2
The deduced protein contains 454 amino acids and has a calculated molecular mass of 55 kD. Northern blot analysis detected Grasp55 expression at variable levels in all rat tissues examined. Cryoelectron microscopy revealed that Grasp55 was expressed on the medial Golgi in transfected HeLa cells.
Blzf1 interacts with Grasp55 and with the GTP-bound form of Rab2, but not with other Golgi Rab proteins. They concluded that Grasp55 and Blzf1 form a Rab2 effector complex on medial Golgi essential for normal protein transport and Golgi structure.recombinant rat Grasp55 and antibodies to the protein blocked the stacking of Golgi cisternae in a cell-free system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Reassembly Stacking Protein 2 (GORASP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Reassembly Stacking Protein 2 (GORASP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Reassembly Stacking Protein 2 (GORASP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Reassembly Stacking Protein 2 (GORASP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Reassembly Stacking Protein 2 (GORASP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Reassembly Stacking Protein 2 (GORASP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Reassembly Stacking Protein 2 (GORASP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Reassembly Stacking Protein 2 (GORASP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Reassembly Stacking Protein 2 (GORASP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Reassembly Stacking Protein 2 (GORASP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Reassembly Stacking Protein 2 (GORASP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Reassembly Stacking Protein 2 (GORASP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Reassembly Stacking Protein 2 (GORASP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Reassembly Stacking Protein 2 (GORASP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Reassembly Stacking Protein 2 (GORASP2) ELISA Kit Customized Service Offer
  1. "Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55."EMBO J. 19:6427-6439(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2."Mol. Biol. Cell 12:1811-1817(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system."EMBO J. 18:4949-4960(1999) [PubMed] [Europe PMC] [Abstract]
  8. "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic."J. Cell Biol. 155:877-883(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus."J. Cell Biol. 155:885-891(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells."J. Cell Sci. 120:2454-2466(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Pentameric assembly of potassium channel tetramerization domain-containing protein 5."J. Mol. Biol. 387:175-191(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Structure of the membrane-tethering GRASP domain reveals a unique PDZ ligand interaction that mediates Golgi biogenesis."J. Biol. Chem. 286:20125-20129(2011) [PubMed] [Europe PMC] [Abstract]