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Golgi Phosphoprotein 3 (GOLPH3)

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GPP34; GOPP1; MIDAS; Golgi Peripheral Membrane Protein 1,34 kDa; Mitochondrial DNA absence factor; Coat protein GPP34; Golgi-Associated Protein

Golgi Phosphoprotein 3 (GOLPH3)
CCC H989
HGNC 15452
MGI 1913879
PubMed 19837035
RGD 621226
UniProt Q9H4A6
Wiki Golph3
GOLPH3 encodes a deduced 298-amino acid protein. Immunogold electron microscopy localized rat Golph3 at the periphery of Golgi stacks, on the cis and trans sides, as well as at the lateral edges of stacked cisternae. Scanning confocal microscopy of cultured rat hippocampal neurons and a rat fibroblast cell line confirmed the Golgi localization and more diffuse cytosolic labeling.Upregulation of MIDAS in HeLa cells caused an increase in mitochondria number, redistributed mitochondria to the perinuclear region, and prevented cell growth. MIDAS had no effect on mitochondria membrane potential, cytoskeletal structure, or mitochondrial DNA, RNA or protein, but the amount of the mitochondria-specific phospholipid cardiolipin was increased almost 2-fold following MIDAS overexpression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Phosphoprotein 3 (GOLPH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Phosphoprotein 3 (GOLPH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Phosphoprotein 3 (GOLPH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Phosphoprotein 3 (GOLPH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Phosphoprotein 3 (GOLPH3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Phosphoprotein 3 (GOLPH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Phosphoprotein 3 (GOLPH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Phosphoprotein 3 (GOLPH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Phosphoprotein 3 (GOLPH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Phosphoprotein 3 (GOLPH3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Phosphoprotein 3 (GOLPH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Phosphoprotein 3 (GOLPH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Phosphoprotein 3 (GOLPH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Phosphoprotein 3 (GOLPH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Phosphoprotein 3 (GOLPH3) ELISA Kit Customized Service Offer
  1. "Proteomics characterization of abundant Golgi membrane proteins."J. Biol. Chem. 276:5152-5165(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction."J. Cell Sci. 118:5357-5367(2005) [PubMed] [Europe PMC] [Abstract]
  7. "GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding."Cell 139:337-351(2009) [PubMed] [Europe PMC] [Abstract]
  8. "GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer."Nature 459:1085-1090(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion."J. Biol. Chem. 287:27637-27647(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1."J. Biol. Chem. 287:39564-39577(2012) [PubMed] [Europe PMC] [Abstract]
  13. "A conserved N-terminal arginine-motif in GOLPH3-family proteins mediates binding to coatomer."Traffic 13:1496-1507(2012) [PubMed] [Europe PMC] [Abstract]
  14. "GOLPH3 regulates the migration and invasion of glioma cells though RhoA."Biochem. Biophys. Res. Commun. 433:338-344(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Functional Characterization of Human Myosin-18A and its Interaction with F-actin and GOLPH3."J. Biol. Chem. 288:30029-30041(2013) [PubMed] [Europe PMC] [Abstract]
  16. "GOLPH3L antagonizes GOLPH3 to determine Golgi morphology."Mol. Biol. Cell 24:796-808(2013) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking."J. Cell Biol. 187:967-975(2009) [PubMed] [Europe PMC] [Abstract]