≡

Glyceronephosphate-O-Acyltransferase (GNPAT)

[Edit]

DHAPAT; DAPAT; DAP-AT; Dihydroxyacetone phosphate acyltransferase; Acyl-CoA:dihydroxyacetonephosphateacyltransferase

Glyceronephosphate-O-Acyltransferase (GNPAT)
CCC H999
HGNC 4416
MGI 1343460
PubMed 21990100
RGD 620179
UniProt O15228
Dihydroxyacetonephosphate acyltransferase, a key enzyme in the biosynthesis of ether phospholipids, is localized exclusively within peroxisomes. Thai et al. (1997) extracted the DHAPAT enzyme from rabbit Harderian gland peroxisomes. From peptide sequences matching EST clones, they isolated a DHAPAT cDNA by screening a human brain cDNA library. The DHAPAT cDNA encodes a 680-amino acid peptide containing a C-terminal type 1 peroxisomal targeting signal (PTS1).
Ofman et al. (1998) determined the N-terminal amino acid sequence of the enzyme isolated from human placenta and used this sequence to identify a DHAPAT cDNA. They confirmed that DHAPAT contains a PTS1 sequence (alanine-glycine-leucine) at the extreme C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glyceronephosphate-O-Acyltransferase (GNPAT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glyceronephosphate-O-Acyltransferase (GNPAT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glyceronephosphate-O-Acyltransferase (GNPAT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glyceronephosphate-O-Acyltransferase (GNPAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glyceronephosphate-O-Acyltransferase (GNPAT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glyceronephosphate-O-Acyltransferase (GNPAT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glyceronephosphate-O-Acyltransferase (GNPAT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glyceronephosphate-O-Acyltransferase (GNPAT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glyceronephosphate-O-Acyltransferase (GNPAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glyceronephosphate-O-Acyltransferase (GNPAT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glyceronephosphate-O-Acyltransferase (GNPAT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glyceronephosphate-O-Acyltransferase (GNPAT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glyceronephosphate-O-Acyltransferase (GNPAT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glyceronephosphate-O-Acyltransferase (GNPAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glyceronephosphate-O-Acyltransferase (GNPAT) ELISA Kit Customized Service Offer
  1. "Ether lipid biosynthesis: isolation and molecular characterization of human dihydroxyacetonephosphate acyltransferase."FEBS Lett. 420:205-211(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Acyl-CoA:dihydroxyacetonephosphate acyltransferase: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2."Hum. Mol. Genet. 7:847-853(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Etherphospholipid biosynthesis and dihydroxyactetone-phosphate acyltransferase: resolution of the genomic organization of the human GNPAT gene and its use in the identification of novel mutations."Biochem. Biophys. Res. Commun. 281:754-760(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3."Hum. Mutat. 33:189-197(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Impaired membrane traffic in defective ether lipid biosynthesis."Hum. Mol. Genet. 10:127-136(2001) [PubMed] [Europe PMC] [Abstract]