Hemopoietic Microenvironment Injury (HMI)

Aplastic anemia(AA) is a disease,including congenital AA and acquired AA,characterized by an extremely hypocellular marrow and peripheral blood pancytopenia due to bone marrow failure.Congenital AA is a autosomal recessive disease due to gene mutation.Persently,acquired AA is recognized as a disease caused by destruction of hematopoietic stem cells,defective marrow microenvironment and aberrant T cellular-immunity.In order to further study its pathogenesis and to choose effective therapeutic target,it has important clinical significance to establish correspondent animal model based on different pathogenesis.