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Guanosine Monophosphate Reductase 1 (GMPR1)

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GMPR; Guanosine 5'-monophosphate oxidoreductase 1

Guanosine Monophosphate Reductase 1 (GMPR1)
CCC J018
HGNC 4376
MGI 1913605
PubMed 12009299
RGD 70980
UniProt P36959
Guanosine monophosphate reductase (EC 1.7.1.7) catalyzes the irreversible NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). GMPR is able to convert guanosine nucleotides to the pivotal precursor of both guanine (G) and adenine (A) nucleotides.
GMPR gene spans about 50 kb and contains 9 exons. The gene contains 2 potential Sp1 binding sites within exon 1, and a functional, atypical polyadenylation signal in exon 9.The frequency of the ile256 variant was thought to be about 30%. A silent C-to-T change at codon 630 was also found, with a frequency of about 10%; the silent change created an additional restriction cleavage site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanosine Monophosphate Reductase 1 (GMPR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanosine Monophosphate Reductase 1 (GMPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanosine Monophosphate Reductase 1 (GMPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanosine Monophosphate Reductase 1 (GMPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanosine Monophosphate Reductase 1 (GMPR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanosine Monophosphate Reductase 1 (GMPR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanosine Monophosphate Reductase 1 (GMPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanosine Monophosphate Reductase 1 (GMPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanosine Monophosphate Reductase 1 (GMPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanosine Monophosphate Reductase 1 (GMPR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanosine Monophosphate Reductase 1 (GMPR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanosine Monophosphate Reductase 1 (GMPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanosine Monophosphate Reductase 1 (GMPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanosine Monophosphate Reductase 1 (GMPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanosine Monophosphate Reductase 1 (GMPR1) ELISA Kit Customized Service Offer
  1. "Two structural genes on different chromosomes are required for encoding the major subunit of human red cell glucose-6-phosphate dehydrogenase."Cell 58:595-606(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure and expression of human guanosine monophosphate reductase."Hum. Genet. 88:219-224(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human mRNA that provides the N-terminus of chimeric G6PD encodes GMP reductase."Cell 58:1021-1022(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Origin of 'fused' glucose-6-phosphate dehydrogenase."Cell 62:11-12(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of human guanosine monophosphate reductase GMPR1 in complex with GMP."Submitted (JUL-2005) to the PDB data bank
  9. "Identification of common variant alleles of the human guanosine monophosphate reductase gene."Hum. Genet. 88:225-227(1991) [PubMed] [Europe PMC] [Abstract]