Glutamate Dehydrogenase 2 (GLUD2)

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GLUDP1

Glutamate Dehydrogenase 2 (GLUD2)
Glutamate dehydrogenase catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate using NAD and/or NADP as cofactors. A novel cDNA encoded by an X-linked intronless gene was cloned. Reverse transcription-polymerase chain reaction analysis of human tissues demonstrated that the novel cDNA is expressed in human retina, testis, and, at a lower level, brain. In vitro translation of mRNAs derived from GLUD1 and the new gene, called GLUD2, generated proteins with distinct electrophoretic characteristics. The retinal cDNA was expressed in the baculovirus heterologous system, producing a protein capable of catalyzing the oxidative deamination of glutamate. Expression of the GLUD2 gene in human retina was of particular interest in view of the finding that glutamate is an important retinal excitatory transmitter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutamate Dehydrogenase 2 (GLUD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutamate Dehydrogenase 2 (GLUD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutamate Dehydrogenase 2 (GLUD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutamate Dehydrogenase 2 (GLUD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutamate Dehydrogenase 2 (GLUD2) ELISA Kit Customized Service Offer
  1. "Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene."J. Biol. Chem. 269:16971-16976(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes."FEBS Lett. 579:4125-4130(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Alpha helical structures in the leader sequence of human GLUD2 glutamate dehydrogenase responsible for mitochondrial import."Neurochem. Int. 61:463-469(2012) [PubMed] [Europe PMC] [Abstract]