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Glycerol Kinase (GK)

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GK1; GKD; Glycerokinase; ATP:glycerol 3-phosphotransferase

Glycerol Kinase (GK)
CCC J030
HGNC 4289
MGI 106594
PubMed 11479736
RGD 70893
UniProt P32189
Wiki GK
Glycerol kinase (EC 2.7.1.30) catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Analysis of DNA from somatic cell hybrids carrying deleted X chromosomes showed that this clone detected homologous sequences between Xp22.1-p21.2, the interval containing the locus responsible for glycerol kinase deficiency.
Northern blot analysis showed 3 GK mRNA transcript sizes of 1.85, 2.7, and 3.7 kb. Expression of the GK gene was found in several human tissues, including skeletal muscle, kidney, and brain, with the highest expression in liver.GK1 locus on Xp21.3 is more than 50 kb long and comprises at least 19 exons. In contrast, the remaining members of the glycerol kinase gene family, located on chromosomes 1, 4, and Xq, appear to be intronless.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycerol Kinase (GK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycerol Kinase (GK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycerol Kinase (GK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycerol Kinase (GK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycerol Kinase (GK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycerol Kinase (GK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycerol Kinase (GK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycerol Kinase (GK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycerol Kinase (GK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycerol Kinase (GK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycerol Kinase (GK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycerol Kinase (GK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycerol Kinase (GK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycerol Kinase (GK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycerol Kinase (GK) ELISA Kit Customized Service Offer
  1. "Genomic scanning for expressed sequences in Xp21 identifies the glycerol kinase gene."Nat. Genet. 4:367-372(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons."Hum. Mol. Genet. 3:1317-1324(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Five cases of isolated glycerol kinase deficiency, including two families: failure to find genotype:phenotype correlation."J. Med. Genet. 37:434-441(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning of the X-linked glycerol kinase deficiency gene and its identification by sequence comparison to the Bacillus subtilis homologue."Hum. Mol. Genet. 2:97-106(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation of the human Xp21 glycerol kinase gene by positional cloning."Hum. Mol. Genet. 2:107-114(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations and phenotype in isolated glycerol kinase deficiency."Am. J. Hum. Genet. 58:1205-1211(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Clinical heterogeneity and novel mutations in the glycerol kinase gene in three families with isolated glycerol kinase deficiency."J. Med. Genet. 35:650-656(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic trait."Am. J. Hum. Genet. 66:1558-1568(2000) [PubMed] [Europe PMC] [Abstract]