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Growth Factor, Independent 1B (GFI1B)

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Potential Regulator Of CDKN1A,Translocated In CML; Growth Factor Independent 1B Transcription Repressor; Zinc finger protein Gfi-1b

Growth Factor, Independent 1B (GFI1B)
CCC J040
HGNC 4238
MGI 1276578
PubMed 22668850
RGD 1311727
UniProt Q5VTD9
Wiki GFI1B
Gfi1b was downregulated in myelomonocytic M1 cells in the presence of interleukin-6 (IL6). However, forced expression of Gfi1b inhibited IL6-induced cell cycle arrest and differentiation and inhibited expression of the p21(WAF1) (CDKN1A) promoter. The inhibition was attributed to a transcriptional repressor contained in the Gfi1b SNAG domain.
Gfi1b encodes a 330-amino acid zinc finger protein with a SNAG repressor domain. Gfi1b is 97% identical in the zinc finger domain and 95% identical in the SNAG domain to Gfi1. Northern blot analysis showed that Gfi1b is expressed in bone marrow and spleen but not in kidney, liver, lung, heart, or brain. In contrast, Gfi1 is expressed primarily in bone marrow and thymus.GFI1B is spread over 5 kb and contains 6 coding exons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Factor, Independent 1B (GFI1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Factor, Independent 1B (GFI1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Factor, Independent 1B (GFI1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Factor, Independent 1B (GFI1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Factor, Independent 1B (GFI1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Factor, Independent 1B (GFI1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Factor, Independent 1B (GFI1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Factor, Independent 1B (GFI1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Factor, Independent 1B (GFI1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Factor, Independent 1B (GFI1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Factor, Independent 1B (GFI1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Factor, Independent 1B (GFI1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Factor, Independent 1B (GFI1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Factor, Independent 1B (GFI1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Factor, Independent 1B (GFI1B) ELISA Kit Customized Service Offer
  1. "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases."Genomics 54:580-582(1998) [PubMed] [Europe PMC] [Abstract]
  2. "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene."Nucleic Acids Res. 32:3935-3946(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis."Blood 100:2769-2777(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism."J. Cell. Biochem. 89:1005-1018(2003) [PubMed] [Europe PMC] [Abstract]
  7. "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells."Nucleic Acids Res. 33:5331-5342(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin."EMBO J. 25:2409-2419(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development."Proc. Natl. Acad. Sci. U.S.A. 103:9976-9981(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1."Blood 110:3128-3135(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas."Blood 109:4406-4414(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate."Br. J. Haematol. 136:212-219(2007) [PubMed] [Europe PMC] [Abstract]
  13. "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription."Mol. Cell. Biol. 27:4261-4272(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain."J. Cell Sci. 125:993-1002(2012) [PubMed] [Europe PMC] [Abstract]
  15. "GFI1B mutation causes a bleeding disorder with abnormal platelet function."J. Thromb. Haemost. 11:2039-2047(2013) [PubMed] [Europe PMC] [Abstract]
  16. "A dominant-negative GFI1B mutation in the gray platelet syndrome." N. Engl. J. Med. 370:245-253(2014) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]