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Ganglioside Induced Differentiation Associated Protein 1 (GDAP1)

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Ganglioside Induced Differentiation Associated Protein 1 (GDAP1)
CCC J043
HGNC 15968
MGI 1338002
PubMed 15772096
RGD 1309005
UniProt Q8TB36
Wiki GDAP1
GDAP1 encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms have been identified for this gene.
The deduced 358-amino acid human GDAP1 protein is 94% identical to the mouse protein, with most divergence at the N terminus. Northern blot analysis revealed expression of a 4.1-kb Gdap1 transcript restricted to mouse brain tissue. Immunofluorescence microscopy demonstrated cytoplasmic expression in mouse cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) ELISA Kit Customized Service Offer
  1. "Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene."J. Neurochem. 72:1781-1790(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The GST domain of GDAP1 is a frequent target of mutations in the dominant form of axonal Charcot Marie Tooth type 2K."J. Med. Genet. 47:712-716(2010) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The gene encoding ganglioside-induced differentiation-associated protein 1 is mutated in axonal Charcot-Marie-Tooth type 4A disease."Nat. Genet. 30:22-25(2002) [PubMed] [Europe PMC] [Abstract]
  7. "GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria."Hum. Mol. Genet. 14:1087-1094(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease."J. Cell Biol. 170:1067-1078(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase."Biochem. Biophys. Res. Commun. 347:859-866(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria."Nat. Cell Biol. 17:160-169(2015) [PubMed] [Europe PMC] [Abstract]
  12. "Ganglioside-induced differentiation-associated protein-1 is mutant in Charcot-Marie-Tooth disease type 4A/8q21."Nat. Genet. 30:21-22(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in GDAP1: autosomal recessive CMT with demyelination and axonopathy."Neurology 59:1865-1872(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Variability of disease progression in a family with autosomal recessive CMT associated with a S194X and new R310Q mutation in the GDAP1 gene."Neuromuscul. Disord. 13:341-346(2003) [PubMed] [Europe PMC] [Abstract]
  15. "CMT4A: identification of a Hispanic GDAP1 founder mutation."Ann. Neurol. 53:400-405(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in the ganglioside-induced differentiation-associated protein-1 (GDAP1) gene in intermediate type autosomal recessive Charcot-Marie-Tooth neuropathy."Brain 126:642-649(2003) [PubMed] [Europe PMC] [Abstract]
  17. "The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan."PLoS ONE 6:E29393-E29393(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges."J. Neurol. 261:970-982(2014) [PubMed] [Europe PMC] [Abstract]