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Gem Associated Protein 5 (GEMIN5)

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Gem Associated Protein 5 (GEMIN5)
CCC J045
HGNC 20043
MGI 2449311
PubMed 11714716
UniProt Q8TEQ6
Wiki GEMIN5
GEMIN5 is part of a large macromolecular complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN, GEMIN2 (SIP1), GEMIN3 (DDX20), and GEMIN4.
The deduced 1,508-amino acid protein has a calculated molecular mass of 169 kD and contains up to 13 WD repeats in its N terminus and a coiled-coil motif near the C terminus. GEMIN5 migrates as a 170-kD protein by Western blot analysis of SMN macromolecular complexes. Immunofluorescence microscopy of HeLa cells revealed strong general staining throughout the cytoplasm and weaker but significant staining of nuclear foci and colocalization of GEMIN5 with SMN in gems.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Associated Protein 5 (GEMIN5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Associated Protein 5 (GEMIN5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Associated Protein 5 (GEMIN5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Associated Protein 5 (GEMIN5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Associated Protein 5 (GEMIN5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Associated Protein 5 (GEMIN5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Associated Protein 5 (GEMIN5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Associated Protein 5 (GEMIN5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Associated Protein 5 (GEMIN5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Associated Protein 5 (GEMIN5) ELISA Kit Customized Service Offer
  1. "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins."J. Biol. Chem. 277:5631-5636(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The Gemin5 protein of the SMN complex identifies snRNAs."Mol. Cell 23:273-279(2006) [PubMed] [Europe PMC] [Abstract]
  8. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]