Gastrokine 2 (GKN2)
[Edit]TFIZ1; BLOT; GDDR; VLTI465; Blottin; Down Regulated In Gastric Cancer; Trefoil factor interactions(z) 1
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Gastrokine-2 (GKN2) is a secretory peptide of human gastric surface mucous cells (SMCs). It forms disulfide-linked heterodimers with the trefoil factor family (TFF) peptide TFF1. Binding with TFF2 was also reported. Antral SMCs differ from those of the corpus by their TFF3 expression. GKN2 expression along the antral gland axis, to characterize the continuous regeneration of antral glands, and to investigate the interactions of GKN2 with TFF1, TFF2 and mucins.
Maturation of antral SMCs occurs stepwise via trans-differentiation of TFF3 expressing progenitor cells. The TFF1-GKN2 heterodimer and TFF2 differ haracteristically by their binding to gastric mucins. This points to different physiological functions of TFF1 and TFF2, the latter maybe acting as a “link peptide” for stabilization of the gastric mucus.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ048Hu01 | Recombinant Gastrokine 2 (GKN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ048Hu01 | Polyclonal Antibody to Gastrokine 2 (GKN2) | WB; IHC |
| LAJ048Hu71 | Biotin-Linked Polyclonal Antibody to Gastrokine 2 (GKN2) | WB; IHC; ICC. | |
| MAJ048Hu21 | Monoclonal Antibody to Gastrokine 2 (GKN2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEJ048Hu | ELISA Kit for Gastrokine 2 (GKN2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCJ048Hu | CLIA Kit for Gastrokine 2 (GKN2) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ048Mu01 | Recombinant Gastrokine 2 (GKN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ048Mu01 | Polyclonal Antibody to Gastrokine 2 (GKN2) | WB,IHC |
| LAJ048Mu71 | Biotin-Linked Polyclonal Antibody to Gastrokine 2 (GKN2) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Gastrokine 2 (GKN2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Gastrokine 2 (GKN2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ048Ra01 | Recombinant Gastrokine 2 (GKN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ048Ra01 | Polyclonal Antibody to Gastrokine 2 (GKN2) | WB; IHC; ICC; IP. |
| LAJ048Ra71 | Biotin-Linked Polyclonal Antibody to Gastrokine 2 (GKN2) | WB; IHC; ICC. | |
| LAJ048Ra81 | FITC-Linked Polyclonal Antibody to Gastrokine 2 (GKN2) | WB; IHC; ICC; IF. | |
| MAJ048Ra21 | Monoclonal Antibody to Gastrokine 2 (GKN2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEJ048Ra | ELISA Kit for Gastrokine 2 (GKN2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCJ048Ra | CLIA Kit for Gastrokine 2 (GKN2) | Chemiluminescent immunoassay for Antigen Detection. |
- "Down-regulated full-length novel gene GDDR and its effect on gastric cancer."Zhonghua Yi Xue Za Zhi 83:1166-1168(2003) [PubMed] [Europe PMC] [Abstract]
- "Study on novel gene GDDR related to gastric cancer."Zhonghua Wai Ke Za Zhi 43:10-13(2005) [PubMed] [Europe PMC] [Abstract]
- "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP-C."Biochemistry 44:7967-7975(2005) [PubMed] [Europe PMC] [Abstract]
- "Identification of blottin: a novel gastric trefoil factor family-2 binding protein."Proteomics 6:4235-4245(2006) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]