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Guanine Deaminase (GDA)

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CYPIN; Guanase; Guanine aminase; Guanine aminohydrolase; p51-nedasin

Guanine Deaminase (GDA)
CCC J051
HGNC 4212
MGI 95678
PubMed 20716488
RGD 621617
UniProt Q9Y2T3
Wiki GDA
Guanine deaminase (GDA) catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.Cypin localizes to both pre- and postsynaptic sites, is enriched in dendritic shafts, cofractionates, and associates with membrane-associated guanylate kinase proteins (PSD95/93 and SAP97/102) in the synaptic plasma membranes and vesicles. Cypin also occurs in the epithelial cells of the small intestine, highest at the tips of the intestinal villi, and exclusively at the basal membrane. GST fusion experiments showed that cypin binding to PSD95 occurs through a C-terminal consensus sequence and requires PDZ domains 1 and 2. Overexpression of cypin in rat hippocampal neurons specifically perturbs postsynaptic trafficking of PSD95 and SAP102 , an effect not produced by overexpression of other PDZ ligands.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ051Hu01 Recombinant Guanine Deaminase (GDA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ051Hu21 Monoclonal Antibody to Guanine Deaminase (GDA) WB; IHC; ICC; IP.
PAJ051Hu01 Polyclonal Antibody to Guanine Deaminase (GDA) WB; IHC; ICC/IF
Assay Kits SEJ051Hu ELISA Kit for Guanine Deaminase (GDA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanine Deaminase (GDA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanine Deaminase (GDA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanine Deaminase (GDA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanine Deaminase (GDA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanine Deaminase (GDA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanine Deaminase (GDA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanine Deaminase (GDA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanine Deaminase (GDA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanine Deaminase (GDA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanine Deaminase (GDA) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein."J. Biol. Chem. 274:8175-8180(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor."J. Biol. Chem. 274:32204-32214(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Human guanine deaminase (GUAD) in complex with zinc and its product xanthine."Submitted (JAN-2008) to the PDB data bank