Glial Cells Missing Homolog 1 (GCM1)

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GCMA; hGCMa; Chorion-specific transcription factor GCMa; GCM motif protein 1

Glial Cells Missing Homolog 1 (GCM1)
GCM1 encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
The predicted GCMA protein contains 436 amino acids. The mammalian proteins share a conserved N-terminal region of approximately 150 amino acids that corresponds to the DNA-binding domain of gcm. The gcm motif of GCMA exhibited specific DNA-binding activity similar to that of gcm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cells Missing Homolog 1 (GCM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cells Missing Homolog 1 (GCM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cells Missing Homolog 1 (GCM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cells Missing Homolog 1 (GCM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cells Missing Homolog 1 (GCM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cells Missing Homolog 1 (GCM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cells Missing Homolog 1 (GCM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cells Missing Homolog 1 (GCM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cells Missing Homolog 1 (GCM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cells Missing Homolog 1 (GCM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cells Missing Homolog 1 (GCM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cells Missing Homolog 1 (GCM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cells Missing Homolog 1 (GCM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cells Missing Homolog 1 (GCM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cells Missing Homolog 1 (GCM1) ELISA Kit Customized Service Offer
  1. "The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals."Proc. Natl. Acad. Sci. U.S.A. 93:14912-14916(1996) [PubMed] [Europe PMC] [Abstract]
  2. "A GCM motif protein is involved in placenta-specific expression of human aromatase gene."J. Biol. Chem. 274:32279-32286(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene."Biochem. Biophys. Res. Commun. 278:134-139(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation."Biol. Reprod. 79:914-920(2008) [PubMed] [Europe PMC] [Abstract]