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GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR)

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P35; GFRP

GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR)
CCC J058
HGNC 4194
MGI 2443977
PubMed 8702680
RGD 621746
UniProt P30047
Wiki GCHFR
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Milstien et al. (1996) used peptide sequences to clone the corresponding rat cDNA which encodes an 84-amino acid polypeptide. Northern blotting of rat tissues revealed that an 0.8-kb GFRP transcript was expressed at relatively high levels in liver and kidney and at somewhat lower levels in testis, heart, brain, and lung.GFRP may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTP Cyclohydrolase I Feedback Regulator Protein (GCHFR) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human liver protein map: a reference database established by microsequencing and gel comparison."Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
  5. "GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes."J. Invest. Dermatol. 126:2481-2489(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions."J. Neurochem. 97:1447-1455(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]