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Phosphoribosylglycinamide Formyltransferase (GART)

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PRGS; PGFT; AIRS; GARS; Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylamine-glycine ligase; Phosphoribosylformylglycinamidine cyclo-ligase

Phosphoribosylglycinamide Formyltransferase (GART)
CCC J065
HGNC 4163
MGI 95654
PubMed 2050105
RGD 1308717
UniProt P22102
Wiki GART
GART is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This C terminal-truncated human GARS protein is produced by alternative splicing resulting in the use of a polyadenylation site in the intron between the terminal GARS and the first AIRS exons. The expression of both the GARS and GARS-AIRS-GART proteins is regulated during development of the human cerebellum, while the expression of FGARAT appears to be constitutive. All 3 proteins were found to be expressed at high levels during normal prenatal development of the cerebellum, while the GARS and GARS-AIRS-GART proteins become undetectable in the cerebellum shortly after birth.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoribosylglycinamide Formyltransferase (GART) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoribosylglycinamide Formyltransferase (GART) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylglycinamide Formyltransferase (GART) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylglycinamide Formyltransferase (GART) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylglycinamide Formyltransferase (GART) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoribosylglycinamide Formyltransferase (GART) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoribosylglycinamide Formyltransferase (GART) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylglycinamide Formyltransferase (GART) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylglycinamide Formyltransferase (GART) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylglycinamide Formyltransferase (GART) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoribosylglycinamide Formyltransferase (GART) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoribosylglycinamide Formyltransferase (GART) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylglycinamide Formyltransferase (GART) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylglycinamide Formyltransferase (GART) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylglycinamide Formyltransferase (GART) ELISA Kit Customized Service Offer
  1. "De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli."Nucleic Acids Res. 18:6665-6672(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene."Nucleic Acids Res. 25:3118-3123(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations."Proc. Natl. Acad. Sci. U.S.A. 87:2916-2920(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR."Biochemistry 41:14206-14215(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid."Biochemistry 42:6043-6056(2003) [PubMed] [Europe PMC] [Abstract]
  13. "The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase."Biochemistry 44:9841-9850(2005) [PubMed] [Europe PMC] [Abstract]