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G Antigen 1 (GAGE1)

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CT4.1; Cancer/Testis Antigen Family 4,Member 1; Antigen MZ2-F

G Antigen 1 (GAGE1)
CCC J077
HGNC 4098
PubMed 14607688
UniProt Q13065
GAGE1 belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The GAGE1 cDNA contains a 143-bp insertion, located in the coding sequence near the termination codon, that is absent from the other cDNAs.The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes.
However, the GAGE1 cDNA contains a 143-bp insertion, located in the coding sequence near the termination codon, that is absent from the other cDNAs. GAGE1 transcript in a number of melanoma cell lines derived from different patients but no GAGE1 expression in the normal tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Antigen 1 (GAGE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Antigen 1 (GAGE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Antigen 1 (GAGE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Antigen 1 (GAGE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Antigen 1 (GAGE1) ELISA Kit Customized Service Offer
  1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
  4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]