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Formin Like Protein 1 (FMNL1)

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FHOD4; FMNL; KW-13; C17orf1; C17orf1B; CLL-associated antigen KW-13; Leukocyte formin

Formin Like Protein 1 (FMNL1)
CCC J096
HGNC 1212
MGI 1888994
PubMed 23182705
RGD 1311042
UniProt O95466
Wiki FMNL1
FMNL1 encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.Frl is expressed as a 160-kD cytosolic protein that is highly expressed in spleen, lymph node, and bone marrow cells and that it associates with Rac and profilin.
By sequencing a recombinant cosmid library, Aronsson et al. (1998) identified 2 genes, NIK and C17ORF1B. Northern blot analysis revealed that C17ORF1B is expressed as a 1.8-kb transcript in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin Like Protein 1 (FMNL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin Like Protein 1 (FMNL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin Like Protein 1 (FMNL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin Like Protein 1 (FMNL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin Like Protein 1 (FMNL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin Like Protein 1 (FMNL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin Like Protein 1 (FMNL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin Like Protein 1 (FMNL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin Like Protein 1 (FMNL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin Like Protein 1 (FMNL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin Like Protein 1 (FMNL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin Like Protein 1 (FMNL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin Like Protein 1 (FMNL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin Like Protein 1 (FMNL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin Like Protein 1 (FMNL1) ELISA Kit Customized Service Offer
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17."Hum. Genet. 103:340-345(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing."J. Biol. Chem. 284:33409-33417(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Bi-modal regulation of a formin by srGAP2."J. Biol. Chem. 286:6577-6586(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]