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Formin 2 (FMN2)

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Formin 2 (FMN2)
CCC J097
HGNC 14074
MGI 1859252
PubMed 12447394
UniProt Q9NZ56
By searching an EST database for homologs of FMN, probing a mouse cDNA library, and further searching of the human EST database, Leader and Leder (2000) identified a mouse cDNA and a partial human cDNA encoding FMN2. Sequence analysis predicted that the 1,567-amino acid mouse protein and the partial human protein share approximately 79% identity at their N termini and 90% identity over their C termini. They also have high homology to the Drosophila 'cappuccino' protein. The FH1 domain of Fmn2 contains 11 proline repeats. Northern blot analysis revealed expression of a 6- to 7-kb FMN2 transcript in all central nervous system tissues and in fetal brain. Whole mount in situ hybridization analysis detected predominant expression of Fmn2 in mouse embryonic spinal cord and brain at days 9.5 to 10.5.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin 2 (FMN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin 2 (FMN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin 2 (FMN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin 2 (FMN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin 2 (FMN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin 2 (FMN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin 2 (FMN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin 2 (FMN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin 2 (FMN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin 2 (FMN2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system."Mech. Dev. 93:221-231(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Effects of genistein on beta-catenin signaling and subcellular distribution of actin-binding proteins in human umbilical CD105-positive stromal cells."J. Cell. Physiol. 223:423-434(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Differential role of actin-binding proteins in controlling the adipogenic differentiation of human CD105-positive Wharton's Jelly cells."Biochim. Biophys. Acta 1820:469-481(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21."Mol. Cell 49:922-933(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Biallelic truncating mutations in FMN2, encoding the actin-regulatory protein Formin 2, cause nonsyndromic autosomal-recessive intellectual disability." Am. J. Hum. Genet. 95:721-728(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain (KIND)*formin-2 formin SPIR interaction motif (FSI) complex."J. Biol. Chem. 286:30732-30739(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Structure and function of the interacting domains of Spire and Fmn-family formins."Proc. Natl. Acad. Sci. U.S.A. 108:11884-11889(2011) [PubMed] [Europe PMC] [Abstract]