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Feline Sarcoma Oncogene (FES)

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FPS; Oncogene FES,Feline Sarcoma Virus; c-Fes/Fps Protein; Feline sarcoma/Fujinami avian sarcoma oncogene homolog

Feline Sarcoma Oncogene (FES)
CCC J109
HGNC 3657
MGI 95514
PubMed 1870997
RGD 1564385
UniProt P07332
Wiki FES
FES encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.
The FES protooncogene encodes a cytoplasmic protein tyrosine kinase implicated in growth factor and cytokine receptor signaling. It is involved myelopoiesis and plays a role in regulating the innate immune response.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ109Hu01 Recombinant Feline Sarcoma Oncogene (FES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ109Hu01 Polyclonal Antibody to Feline Sarcoma Oncogene (FES) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Feline Sarcoma Oncogene (FES) CLIA Kit Customized Service Offer
n/a ELISA Kit for Feline Sarcoma Oncogene (FES) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ109Mu01 Recombinant Feline Sarcoma Oncogene (FES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ109Mu01 Polyclonal Antibody to Feline Sarcoma Oncogene (FES) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Feline Sarcoma Oncogene (FES) CLIA Kit Customized Service Offer
n/a ELISA Kit for Feline Sarcoma Oncogene (FES) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Feline Sarcoma Oncogene (FES) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Feline Sarcoma Oncogene (FES) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Feline Sarcoma Oncogene (FES) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Feline Sarcoma Oncogene (FES) CLIA Kit Customized Service Offer
n/a ELISA Kit for Feline Sarcoma Oncogene (FES) ELISA Kit Customized Service Offer
  1. "Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene."Oncogene 5:267-275(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The structure of the human c-fes/fps proto-oncogene."EMBO J. 4:2897-2903(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation."J. Biol. Chem. 264:10276-10281(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713)."Oncogene 8:2283-2292(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues."J. Biol. Chem. 271:32930-32936(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking."Exp. Cell Res. 266:87-94(2001) [PubMed] [Europe PMC] [Abstract]
  10. "A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells."Mol. Cell. Biol. 21:6170-6180(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Closing in on the biological functions of Fps/Fes and Fer."Nat. Rev. Mol. Cell Biol. 3:278-289(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner."Exp. Cell Res. 299:188-198(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly."Mol. Cell. Biol. 24:9351-9358(2004) [PubMed] [Europe PMC] [Abstract]
  14. "An identity crisis for fps/fes: oncogene or tumor suppressor?"Cancer Res. 65:3518-3522(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Expression of c-Fes protein isoforms correlates with differentiation in myeloid leukemias."DNA Cell Biol. 24:311-316(2005) [PubMed] [Europe PMC] [Abstract]
  16. "The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase."Biochem. J. 399:141-150(2006) [PubMed] [Europe PMC] [Abstract]
  17. "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer."J. Biol. Chem. 281:8829-8835(2006) [PubMed] [Europe PMC] [Abstract]
  18. "The tyrosine kinase FES is an essential effector of KITD816V proliferation signal."Blood 110:2593-2599(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering."EMBO J. 27:38-50(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells."Biochemistry 48:4780-4788(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer."Genes Chromosomes Cancer 48:272-284(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells."Int. J. Oncol. 34:89-96(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells."Mol. Cell. Biol. 29:389-401(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  25. "FES kinases are required for oncogenic FLT3 signaling."Leukemia 24:721-728(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Structure and regulation of the c-Fes protein-tyrosine kinase."Front. Biosci. 16:3146-3155(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer."Prostate 72:201-208(2012) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes."J. Biomol. NMR 31:357-361(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation."Cell 134:793-803(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]