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Fc Receptor Like Protein 4 (FCRL4)

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CD307d; FCRH4; IGFP2; IRTA1; Fc receptor homolog 4; IFGP family protein 2; Immune receptor translocation-associated protein 1

Fc Receptor Like Protein 4 (FCRL4)
CCC J110
HGNC 18507
PubMed 21908428
UniProt Q96PJ5
Wiki FCRL4
FCRL4 encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.
Specifically expressed by memory and monocytoid B cells which populate spleen and lymph nodes. Preferentially expressed in memory B cells associated with mucosal tissue (at protein level).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ110Hu01 Recombinant Fc Receptor Like Protein 4 (FCRL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Fc Receptor Like Protein 4 (FCRL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Receptor Like Protein 4 (FCRL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Receptor Like Protein 4 (FCRL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Receptor Like Protein 4 (FCRL4) ELISA Kit Customized Service Offer
  1. "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy."Immunity 14:277-289(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a family of Fc receptor homologs with preferential B cell expression."Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract]
  3. "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1."Immunogenetics 54:87-95(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)."Blood 102:3684-3692(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding and fluorescence in situ hybridization analysis."Genes Chromosomes Cancer 36:375-381(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The inhibitory potential of Fc receptor homolog 4 on memory B cells."Proc. Natl. Acad. Sci. U.S.A. 100:13489-13494(2003) [PubMed] [Europe PMC] [Abstract]
  9. "T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution."Haematologica 90:1070-1077(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells."J. Exp. Med. 202:783-791(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]