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Fc Receptor Like Protein 2 (FCRL2)

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CD307b; SPAP1; FCRH2; IFGP4; IRTA4; Immunoglobulin receptor translocation-associated protein 4; SH2 Domain-Containing Phosphatase Anchor Protein 1

Fc Receptor Like Protein 2 (FCRL2)
CCC J112
HGNC 14875
PubMed 21068405
UniProt Q96LA5
Wiki FCRL2
FCRL2 encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs.
The deduced 255-amino acid transmembrane protein contains 2 ITIMs. Further searches and sequencing identified a 192-amino acid splice variant, SPAP1B, lacking the intracellular ITIMs, and a 144-amino acid isoform, SPAP1C, lacking the transmembrane segment. This protein may be a prognostic marker for chronic lymphocytic leukemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ112Hu01 Recombinant Fc Receptor Like Protein 2 (FCRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Fc Receptor Like Protein 2 (FCRL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Receptor Like Protein 2 (FCRL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Receptor Like Protein 2 (FCRL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Receptor Like Protein 2 (FCRL2) ELISA Kit Customized Service Offer
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  2. "Molecular cloning and characterization of SPAP1, an inhibitory receptor."Biochem. Biophys. Res. Commun. 280:768-775(2001) [PubMed] [Europe PMC] [Abstract]
  3. "IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
  4. "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1."Immunogenetics 54:87-95(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]