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Fc Receptor Like Protein 3 (FCRL3)

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CD307c; FCRH3; IFGP3; IRTA3; SPAP2; IFGP family protein 3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2

Fc Receptor Like Protein 3 (FCRL3)
CCC J113
HGNC 18506
MGI 3053558
PubMed 22392608
RGD 1589379
UniProt Q96P31
Wiki FCRL3
FCRL3 encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Primarily expressed in secondary lymphoid tissues by mature subsets of B cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B cells but also expressed in NK cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fc Receptor Like Protein 3 (FCRL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fc Receptor Like Protein 3 (FCRL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Receptor Like Protein 3 (FCRL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Receptor Like Protein 3 (FCRL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Receptor Like Protein 3 (FCRL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fc Receptor Like Protein 3 (FCRL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fc Receptor Like Protein 3 (FCRL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Receptor Like Protein 3 (FCRL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Receptor Like Protein 3 (FCRL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Receptor Like Protein 3 (FCRL3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fc Receptor Like Protein 3 (FCRL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fc Receptor Like Protein 3 (FCRL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Receptor Like Protein 3 (FCRL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Receptor Like Protein 3 (FCRL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Receptor Like Protein 3 (FCRL3) ELISA Kit Customized Service Offer
  1. "Identification of a family of Fc receptor homologs with preferential B cell expression."Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract]
  2. "SPAP2, an Ig family receptor containing both ITIMs and ITAMs."Biochem. Biophys. Res. Commun. 293:1037-1046(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
  7. "A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities." Nat. Genet. 37:478-485(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis."Ann. Rheum. Dis. 65:671-673(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis."Ann. Rheum. Dis. 65:1188-1191(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?"Arthritis Res. Ther. 8:R117-R117(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population."Arthritis Rheum. 54:3820-3827(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease."J. Clin. Endocrinol. Metab. 91:1056-1061(2006) [PubMed] [Europe PMC] [Abstract]
  14. "FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians."Ann. Rheum. Dis. 66:803-806(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Meta-analysis evidence of a differential risk of the FCRL3 -169T-->C polymorphism in white and East Asian rheumatoid arthritis patients."Arthritis Rheum. 56:3168-3171(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants."Nat. Genet. 39:1329-1337(2007) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]