V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1)

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EWSR2; p54; Protein C-ets-1

V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1)
ETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes.
The human ETS1 gene encodes a deduced 441-amino acid protein that is more than 95% identical to the chicken Ets1 gene product. Human and mouse ETS2 cDNA clones are closely related and encode proteins of 469 and 468 residues, respectively. It is of interest that the equivalent of the ETS1 and ETS2 genes are contiguous, i.e., located on the same chromosome, and are coordinately transcribed in birds.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ130Hu ELISA Kit for V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ130Mu01 Recombinant V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ130Mu02 Recombinant V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ130Mu01 Polyclonal Antibody to V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) WB; IHC; ICC; IP.
PAJ130Mu02 Polyclonal Antibody to V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) WB; IHC; ICC; IP.
Assay Kits SEJ130Mu ELISA Kit for V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) ELISA Kit Customized Service Offer
  1. "Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene."Oncogene Res. 3:239-246(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian ets-1 and ets-2 genes encode highly conserved proteins."Proc. Natl. Acad. Sci. U.S.A. 85:7862-7866(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51."Oncogene 28:2087-2099(2009) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter."Nucleic Acids Res. 20:2699-2703(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies."Leukemia 7:1777-1785(1993) [PubMed] [Europe PMC] [Abstract]
  9. "The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active."Proc. Natl. Acad. Sci. U.S.A. 82:7294-7298(1985) [PubMed] [Europe PMC] [Abstract]
  10. "Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme."Oncogene 15:1489-1495(1997) [PubMed] [Europe PMC] [Abstract]
  11. "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes."Oncogene 19:745-753(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Sp100 interacts with ETS-1 and stimulates its transcriptional activity."Mol. Cell. Biol. 22:2687-2702(2002) [PubMed] [Europe PMC] [Abstract]
  13. "SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion."Oncogene 23:6654-6665(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  15. "SP100 inhibits ETS1 activity in primary endothelial cells."Oncogene 24:916-931(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Transcription factor Ets-1 in cytokine and chemokine gene regulation."Cytokine 51:217-226(2010) [PubMed] [Europe PMC] [Abstract]
  19. "The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation."Cell 83:761-771(1995) [PubMed] [Europe PMC] [Abstract]
  20. "Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization."EMBO J. 27:2006-2017(2008) [PubMed] [Europe PMC] [Abstract]