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Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4)

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DHRS4L2; PSCD; NRDR; PHCR; SDR25C1; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; Peroxisomal short-chain alcohol dehydrogenase

Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4)
CCC J150
HGNC 16985
MGI 90169
PubMed 22891334
RGD 708482
UniProt Q9BTZ2
Wiki DHRS4
By RT-PCR and RACE of a HeLa cell cDNA library, Song et al. (2007) cloned full-length NRDR and a variant lacking exon 3, which they called NRDRB1. The deduced NRDR and NRDRB1 proteins have calculated molecular masses of 29 and 27 kD, respectively. Song et al. (2007) detected NRDRB1 mRNA expression in 14 (53.9%) of 26 cervical cancer tissues, but expression was not detected in 12 normal cervical tissues. Immunohistochemical analysis detected NRDRB1 protein only in tumor tissues. The full-length NRDR mRNA was observed in both normal and neoplastic cervical tissues, but NRDR protein was only expressed in normal cervical epithelium, where it localized in peroxisomes.Fluorescence-tagged rat Dhrs4 localized to peroxisomes in transfected Chinese hamster ovary cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4) ELISA Kit Customized Service Offer
  1. "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase."Biochem. J. 340:561-568(1999) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics."Yi Chuan Xue Bao 31:661-667(2004) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning of a short isoform of human neuroblastoma NADP(H)-dependent retinol dehydrogenase/reductase and analysis of its characteristics."Ai Bian Ji Bian Tu Bian 17:321-326(2005)
  4. "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma."Int. J. Cancer 120:1618-1626(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil."Cell. Physiol. Biochem. 30:1371-1382(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of a novel isoform of DHRS4 protein with a nuclear localization signal."Gene 494:161-167(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]