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Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2)

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BAT8; G9A; NG36; KMT1C; C6orf30; HLA-B Associated Transcript 8; Lysine N-methyltransferase 1C; Histone H3-K9 methyltransferase 3; Histone-lysine N-methyltransferase EHMT2

Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2)
CCC J173
HGNC 14129
MGI 2148922
PubMed 23466651
RGD 1302972
UniProt Q96KQ7
Wiki EHMT2
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region.
EHMT2 was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Euchromatic Histone Lysine-N-Methyltransferase 2 (EHMT2) ELISA Kit Customized Service Offer
  1. "Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions."Mamm. Genome 12:916-924(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats."Biochem. J. 290:811-818(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3."J. Biol. Chem. 276:25309-25317(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells."Science 296:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin."EMBO J. 25:2409-2419(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  13. "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation."Mol. Cell 32:718-726(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Protein lysine methyltransferase G9a acts on non-histone targets."Nat. Chem. Biol. 4:344-346(2008) [PubMed] [Europe PMC] [Abstract]
  15. "The ankyrin repeats of G9a and GLP histone methyltransferases are mono-and dimethyllysine binding modules."Nat. Struct. Mol. Biol. 15:245-250(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells."Nucleic Acids Res. 37:493-505(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "G9a and Glp methylate lysine 373 in the tumor suppressor p53."J. Biol. Chem. 285:9636-9641(2010) [PubMed] [Europe PMC] [Abstract]
  21. ErratumJ. Biol. Chem. 285:18122-18122(2010)
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1."Mol. Cell 42:285-296(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA."Mol. Cell 46:7-17(2012) [PubMed] [Europe PMC] [Abstract]
  26. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  28. "Structural biology of human H3K9 methyltransferases."PLoS ONE 5:E8570-E8570(2010) [PubMed] [Europe PMC] [Abstract]