≡

E4F Transcription Factor 1 (E4F1)

[Edit]

p120E4F; p50E4F; Putative E3 ubiquitin-protein ligase E4F1

E4F Transcription Factor 1 (E4F1)
CCC J187
HGNC 3121
MGI 109530
PubMed 24163401
RGD 1596731
UniProt Q66K89
Wiki E4F1
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.
Specific inactivation of RASSF1A by short interfering RNA disrupted the binding of RASSF1A to E4F1 in immunoprecipitation assays. In addition, there was enhanced G1 cell cycle arrest and S-phase inhibition by E4F1 in the presence of RASSF1A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E4F Transcription Factor 1 (E4F1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E4F Transcription Factor 1 (E4F1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E4F Transcription Factor 1 (E4F1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E4F Transcription Factor 1 (E4F1) CLIA Kit Customized Service Offer
n/a ELISA Kit for E4F Transcription Factor 1 (E4F1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E4F Transcription Factor 1 (E4F1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E4F Transcription Factor 1 (E4F1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E4F Transcription Factor 1 (E4F1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E4F Transcription Factor 1 (E4F1) CLIA Kit Customized Service Offer
n/a ELISA Kit for E4F Transcription Factor 1 (E4F1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E4F Transcription Factor 1 (E4F1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E4F Transcription Factor 1 (E4F1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E4F Transcription Factor 1 (E4F1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E4F Transcription Factor 1 (E4F1) CLIA Kit Customized Service Offer
n/a ELISA Kit for E4F Transcription Factor 1 (E4F1) ELISA Kit Customized Service Offer
  1. "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3."Mol. Cell. Biol. 17:1890-1903(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice."Mamm. Genome 9:320-323(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Adenovirus E1A-regulated transcription factor p120E4F inhibits cell growth and induces the stabilization of the cdk inhibitor p21WAF1."Mol. Cell. Biol. 18:459-467(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Mutational analysis of p50E4F suggests that DNA binding activity is mediated through an alternative structure in a zinc finger domain that is regulated by phosphorylation."Nucleic Acids Res. 26:1681-1688(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Suppression of E1A-mediated transformation by the p50E4F transcription factor."Mol. Cell. Biol. 19:4739-4749(1999) [PubMed] [Europe PMC] [Abstract]
  9. "p53 is involved in the p120E4F-mediated growth arrest."Oncogene 19:188-199(2000) [PubMed] [Europe PMC] [Abstract]
  10. "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F."Proc. Natl. Acad. Sci. U.S.A. 97:7738-7743(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1."Mol. Cell. Biol. 21:2956-2966(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition."J. Biol. Chem. 278:4981-4989(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2."Mol. Cell. Biol. 23:9104-9116(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein."Oncogene 22:2541-2547(2003) [PubMed] [Europe PMC] [Abstract]
  15. "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis."Am. J. Pathol. 165:2019-2031(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene."Cancer Res. 64:102-107(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Transcriptional regulation of cyclin A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin A2 promoter."Cancer Res. 65:2690-2697(2005) [PubMed] [Europe PMC] [Abstract]
  18. "p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners."Cell Cycle 4:597-603(2005) [PubMed] [Europe PMC] [Abstract]
  19. "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation."Cell 127:775-788(2006) [PubMed] [Europe PMC] [Abstract]
  20. "E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells."Genes Dev. 20:2110-2120(2006) [PubMed] [Europe PMC] [Abstract]
  21. "The LIM-only protein FHL2 is a negative regulator of E4F1."Oncogene 25:5475-5484(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro."Virus Res. 115:31-42(2006) [PubMed] [Europe PMC] [Abstract]
  23. "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression."EMBO Rep. 8:671-677(2007) [PubMed] [Europe PMC] [Abstract]
  24. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]