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Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2)

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Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2)
CCC J191
HGNC 3093
MGI 1330301
PubMed 19287380
RGD 1312039
UniProt Q92630
Wiki DYRK2
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.The DYRK2 proteins contain a canonical kinase domain located between a large N-terminal region and a short C-terminal extension, and features specific to DYRK-related kinases. DYRK2 shares 46% identity with DYRK1 in the catalytic domain, but lacks the striking sequence motifs identified in DYRK1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) ELISA Kit Customized Service Offer
  1. "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases."J. Biol. Chem. 273:25893-25902(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase."Biochem. J. 355:609-615(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas."Cancer Res. 63:4136-4143(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation."Mol. Cell. Biol. 23:1546-1557(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases."J. Biol. Chem. 279:2490-2498(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors."J. Biol. Chem. 279:4612-4624(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL."Biochem. J. 389:775-783(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo."J. Biol. Chem. 281:16591-16598(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT."Nature 441:646-650(2006) [PubMed] [Europe PMC] [Abstract]
  12. "DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage."Mol. Cell 25:725-738(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Role for DYRK family kinases on regulation of apoptosis."Biochem. Pharmacol. 76:1389-1394(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling."Cell 133:537-548(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Nuclear trafficking of pro-apoptotic kinases in response to DNA damage."Trends Mol. Med. 14:305-313(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation."FEBS J. 276:6324-6337(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase."Nat. Cell Biol. 11:409-419(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors."Bioorg. Med. Chem. Lett. 20:3491-3494(2010) [PubMed] [Europe PMC] [Abstract]
  19. "ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage."J. Biol. Chem. 285:4909-4919(2010) [PubMed] [Europe PMC] [Abstract]
  20. "DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells."J. Clin. Invest. 122:859-872(2012) [PubMed] [Europe PMC] [Abstract]
  21. "Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways."J. Mol. Cell Biol. 4:316-330(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation."J. Biol. Chem. 288:7252-7262(2013) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand."Submitted (JAN-2010) to the PDB data bank
  24. "Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B."J. Med. Chem. 55:9312-9330(2012) [PubMed] [Europe PMC] [Abstract]
  25. "Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition."Structure 21:986-996(2013) [PubMed] [Europe PMC] [Abstract]
  26. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]