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Dynein, Axonemal, Intermediate Chain 1 (DNAI1)

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PCD; CILD1; ICS; Axonemal dynein intermediate chain 1

Dynein, Axonemal, Intermediate Chain 1 (DNAI1)
CCC J194
HGNC 2954
MGI 1916172
PubMed 22416021
RGD 1565671
UniProt Q9UI46
Wiki DNAI1
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins.
The DNAI1 gene encodes a 699-amino acid protein. Northern blot analysis detected a specific and abundant DNAI1 transcript of approximately 2.5 kb in adult trachea and testis and an additional weakly expressed DNAI1 transcript of approximately 4 kb in trachea.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Intermediate Chain 1 (DNAI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Intermediate Chain 1 (DNAI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Intermediate Chain 1 (DNAI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Intermediate Chain 1 (DNAI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Intermediate Chain 1 (DNAI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Intermediate Chain 1 (DNAI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Intermediate Chain 1 (DNAI1) ELISA Kit Customized Service Offer
  1. "Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia."Am. J. Hum. Genet. 65:1508-1519(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation."J. Biol. Chem. 278:11579-11589(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance."Am. J. Hum. Genet. 92:955-964(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)."Am. J. Hum. Genet. 68:1030-1035(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia."Eur. Respir. J. 44:1579-1588(2014) [PubMed] [Europe PMC] [Abstract]