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Dynein, Axonemal, Intermediate Chain 2 (DNAI2)

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Axonemal dynein intermediate chain 2

Dynein, Axonemal, Intermediate Chain 2 (DNAI2)
CCC J195
HGNC 18744
MGI 2685574
PubMed 18950741
RGD 1359602
UniProt Q9GZS0
Wiki DNAI2
DNAI2 belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
The DNAI2 gene encodes a deduced 605-amino acid protein containing 5 WD-40 repeats and several putative phosphorylation sites. Northern blot analysis revealed high expression of an approximately 2.4-kb DNAI2 transcript in trachea and testis.DNAH5 is essential for correct assembly of DNAI2 in outer dynein complexes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Intermediate Chain 2 (DNAI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Intermediate Chain 2 (DNAI2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Intermediate Chain 2 (DNAI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Intermediate Chain 2 (DNAI2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Intermediate Chain 2 (DNAI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Intermediate Chain 2 (DNAI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Intermediate Chain 2 (DNAI2) ELISA Kit Customized Service Offer
  1. "The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesia."Hum. Genet. 107:642-649(2000) [PubMed] [Europe PMC] [Abstract]
  2. "No deleterious mutations were found in three genes (HFH4, LC8, DNAI2) on human chromosome 17q in patients with primary ciliary dyskinesia."Eur. J. Hum. Genet. 8:126-126(2000)
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm." Am. J. Hum. Genet. 83:547-558(2008) [PubMed] [Europe PMC] [Abstract]
  7. "HEATR2 plays a conserved role in assembly of the ciliary motile apparatus." PLoS Genet. 10:E1004577-E1004577(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia."Eur. Respir. J. 44:1579-1588(2014) [PubMed] [Europe PMC] [Abstract]