Dynein, Axonemal, Heavy Chain 1 (DNAH1)

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets.

Chapelin et al. (1997), Neesen et al. (1997), and Vaughan et al. (1996) isolated partial cDNAs encoding a human dynein heavy chain (DHC) that they designated DNAHC1, HDHC7, and HL-11, respectively. By sequence analysis, Chapelin et al. (1997) determined that DNAHC1 belongs to the putative axonemal inner dynein arm DHC group and is homologous to rat DLP1. RT-PCR assays indicated that DNAHC1 is expressed primarily in trachea and testis, 2 tissues containing axonemal structures.