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Dynein, Axonemal, Heavy Chain 7 (DNAH7)

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hDHC2; Dynein heavy chain-like protein 2; Ciliary dynein heavy chain 7; Axonemal beta dynein heavy chain 7

Dynein, Axonemal, Heavy Chain 7 (DNAH7)
CCC J207
HGNC 18661
MGI 2685838
PubMed 11877439
UniProt Q8WXX0
The deduced 4,025-amino acid protein has a calculated molecular mass of 461.2 kD. DNAH7 contains 4 central P loops, followed by 2 coiled-coil domains and 2 putative ATP-binding sites. Western blot analysis showed that DNAH7 expression was induced following differentiation of human bronchial epithelial cells from basal-like cells to mucociliary epithelium, concomitant with development of cilia. Immunohistochemical analysis revealed intense DNAH7 staining of cilia.
Expression was low in adult brain, and little to no expression was detected in heart, liver, skeletal muscle, pancreas, spleen, and fetal liver. Within specific adult brain regions, low expression was detected in caudate nucleus and subthalamic nucleus, and all other regions showed little to no expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Heavy Chain 7 (DNAH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Heavy Chain 7 (DNAH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Heavy Chain 7 (DNAH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Heavy Chain 7 (DNAH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Heavy Chain 7 (DNAH7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Heavy Chain 7 (DNAH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Heavy Chain 7 (DNAH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Heavy Chain 7 (DNAH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Heavy Chain 7 (DNAH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Heavy Chain 7 (DNAH7) ELISA Kit Customized Service Offer
  1. "Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia."J. Biol. Chem. 277:17906-17915(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes."Eur. J. Hum. Genet. 8:923-932(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene."Gene 200:193-202(1997) [PubMed] [Europe PMC] [Abstract]