The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX2, resides within these 3.3-kb repeated elements .
Using PCR amplification of genomic DNA with primers from HEFT1, a genomic sequence identified as a DNA-binding target of HLTF (SMARCA3), Ding et al. (1998) cloned DUX2. The deduced 80-amino acid protein shares 70% amino acid identity with DUX1, but the DUX2 sequence stops just after the first homeodomain.
Ding et al. (1998) determined that the HEFT1 sequence, which presents a consensus GC and TATAA box, and DUX1 sequences were not associated in the genome; however, DUX2 was found carrying a promoter identical to HEFT1.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Double Homeobox Protein 2 (DUX2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Double Homeobox Protein 2 (DUX2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Double Homeobox Protein 2 (DUX2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Double Homeobox Protein 2 (DUX2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Double Homeobox Protein 2 (DUX2) | ELISA Kit Customized Service Offer |