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Deubiquitinating Enzyme 3 (DUB3)

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USP17L2; Ubiquitin Specific Peptidase 17-Like 2; Ubiquitin carboxyl-terminal hydrolase 17; Ubiquitin-specific-processing protease 17-like protein 2

Deubiquitinating Enzyme 3 (DUB3)
CCC J223
HGNC 34434
PubMed 14699124
UniProt Q6R6M4
The deduced 530-amino acid protein shares approximately 44% overall sequence identity with the mouse Dub sequences and approximately 56% identity over the catalytic core, which contains UBP conserved domains I-VI and active site cysteine, aspartate, and histidine residues. DUB3 also contains a conserved 19-amino acid sequence that is present in 2 or 3 copies in mouse Dub sequences. Northern blot analysis detected 2 DUB3 transcripts: a 1.6-kb transcript in several tissues including heart, skeletal muscle, colon, kidney, and liver, and a 1.7-kb transcript in brain and liver. The 1.6-kb transcript was also detected at high levels in numerous cell lines derived from hematopoietic tumors such as a Burkitt lymphoma cell line as well as in solid tumors. In contrast, little DUB3 expression was detected in normal peripheral blood leukocytes and spleen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deubiquitinating Enzyme 3 (DUB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deubiquitinating Enzyme 3 (DUB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deubiquitinating Enzyme 3 (DUB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deubiquitinating Enzyme 3 (DUB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deubiquitinating Enzyme 3 (DUB3) ELISA Kit Customized Service Offer
  1. "DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation."J. Biol. Chem. 279:13993-14000(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
  5. "USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity."J. Biol. Chem. 284:9587-9595(2009) [PubMed] [Europe PMC] [Abstract]
  6. "The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster."BMC Genomics 11:250-250(2010) [PubMed] [Europe PMC] [Abstract]
  7. "The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression."Cancer Res. 70:3329-3339(2010) [PubMed] [Europe PMC] [Abstract]
  8. "The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling."Cell Res. 20:802-811(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected."J. Biol. Chem. 285:12028-12036(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A."Nat. Cell Biol. 12:400-406(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity."J. Biol. Chem. 286:10505-10514(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility."Nat. Commun. 2:259-259(2011) [PubMed] [Europe PMC] [Abstract]