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Developmentally Regulated GTP Binding Protein 1 (DRG1)

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NEDD3; Neural precursor cell expressed developmentally down-regulated protein 3

Developmentally Regulated GTP Binding Protein 1 (DRG1)
CCC J232
HGNC 3029
MGI 1343297
PubMed 15676025
RGD 1304993
UniProt Q9Y295
Wiki DRG1
Kumar et al. (1992) isolated Nedd3 and other mouse neural precursor cell cDNAs corresponding to mRNAs that are downregulated during mouse brain development. Sazuka et al. (1992) cloned additional cDNAs corresponding to the entire Nedd3 coding region, and renamed the gene DRG.The predicted protein contains structural motifs characteristic of GTP-binding proteins, and recombinant DRG protein bound GTP in vitro. By carrying out a yeast 2-hybrid screen with the SCL protein as bait, Zhao and Aplan (1998) isolated a fetal liver cDNA encoding the human homolog of DRG. The deduced 367-amino acid human and mouse DRG proteins are identical except at 1 amino acid position. The authors noted that this DRG protein is distinct from DRG2, which had previously been designated DRG.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Developmentally Regulated GTP Binding Protein 1 (DRG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Developmentally Regulated GTP Binding Protein 1 (DRG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Developmentally Regulated GTP Binding Protein 1 (DRG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Developmentally Regulated GTP Binding Protein 1 (DRG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Developmentally Regulated GTP Binding Protein 1 (DRG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Developmentally Regulated GTP Binding Protein 1 (DRG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Developmentally Regulated GTP Binding Protein 1 (DRG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Developmentally Regulated GTP Binding Protein 1 (DRG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Developmentally Regulated GTP Binding Protein 1 (DRG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Developmentally Regulated GTP Binding Protein 1 (DRG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Developmentally Regulated GTP Binding Protein 1 (DRG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Developmentally Regulated GTP Binding Protein 1 (DRG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Developmentally Regulated GTP Binding Protein 1 (DRG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Developmentally Regulated GTP Binding Protein 1 (DRG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Developmentally Regulated GTP Binding Protein 1 (DRG1) ELISA Kit Customized Service Offer
  1. "SCL binds the human homologue of DRG in vivo."Biochim. Biophys. Acta 1448:109-114(1998) [PubMed] [Europe PMC] [Abstract]
  2. "DRG represents a family of two closely related GTP-binding proteins."Biochim. Biophys. Acta 1491:196-204(2000) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2."Genes Cells 10:139-150(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation."Nucleic Acids Res. 35:E109-E109(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture."Structure 16:115-124(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells."Biochem. Biophys. Res. Commun. 390:552-556(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structures of the TGS domain of human developmentally-regulated GTP-binding protein 1."Submitted (SEP-2007) to the PDB data bank