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Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1)

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CDGIE; MPDS; Dolichyl-phosphate beta-D-mannosyltransferase subunit 1; Dolichol-phosphate mannose synthase subunit 1; Mannose-P-dolichol synthase subunit 1

Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1)
CCC J238
HGNC 3005
MGI 1330239
PubMed 16280320
RGD 1310120
UniProt O60762
Wiki DPM1
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
The predicted 260-amino acid human protein shares approximately 30% identity with yeast dpm1. However, DPM1 lacks the C-terminal transmembrane domain found in dpm1 and does not contain a signal sequence.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dolichyl Phosphate Mannosyltransferase Polypeptide 1 (DPM1) ELISA Kit Customized Service Offer
  1. "A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells."J. Biol. Chem. 273:9249-9254(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe."Proc. Natl. Acad. Sci. U.S.A. 94:7873-7878(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3."EMBO J. 19:2475-2482(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3."J. Biol. Chem. 281:896-904(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie)."J. Clin. Invest. 105:191-198(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie."J. Clin. Invest. 105:233-239(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Congenital disorder of glycosylation (CDG) type Ie. A new patient."J. Inherit. Metab. Dis. 27:591-600(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Congenital disorder of glycosylation due to DPM1 mutations presenting with dystroglycanopathy-type congenital muscular dystrophy."Mol. Genet. Metab. 110:345-351(2013) [PubMed] [Europe PMC] [Abstract]