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Diaphanous Homolog 2 (DIAPH2)

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DIA; DIA2; POF; POF2; Diaphanous-related formin-2

Diaphanous Homolog 2 (DIAPH2)
CCC J264
HGNC 2877
MGI 1858500
PubMed 9360932
RGD 1564399
UniProt O60879
Wiki Diaph2
DIAPH2 may play a role in the development and normal function of the ovaries. The use of alternative last exons results in 2 DIAPH2 proteins that differ in their C termini: DIAPH2-156, which uses exon 156 and contains 1,101 amino acids, and DIAPH2-12C, which uses exon 12C and contains 1,096 amino acids.
The sequence encoded by exon 156 is significantly similar to the comparable sequence of Drosophila dia, while the sequence encoded by exon 12C is quite different. DIAPH2-156 and Drosophila dia share about 39% amino acid identity. Both DIAPH2 isoforms contain formin homology-1 (FH1) and FH2 domains that are flanked by 2 coiled-coil domains. DIAPH2 also has a predicted nuclear localization signal near its C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diaphanous Homolog 2 (DIAPH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diaphanous Homolog 2 (DIAPH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diaphanous Homolog 2 (DIAPH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diaphanous Homolog 2 (DIAPH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diaphanous Homolog 2 (DIAPH2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diaphanous Homolog 2 (DIAPH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diaphanous Homolog 2 (DIAPH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diaphanous Homolog 2 (DIAPH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diaphanous Homolog 2 (DIAPH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diaphanous Homolog 2 (DIAPH2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diaphanous Homolog 2 (DIAPH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diaphanous Homolog 2 (DIAPH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diaphanous Homolog 2 (DIAPH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diaphanous Homolog 2 (DIAPH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diaphanous Homolog 2 (DIAPH2) ELISA Kit Customized Service Offer
  1. "A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility."Am. J. Hum. Genet. 62:533-541(1998) [PubMed] [Europe PMC] [Abstract]
  2. "RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase."Nat. Cell Biol. 5:195-204(2003) [PubMed] [Europe PMC] [Abstract]
  3. ErratumNat. Cell Biol. 5:680-680(2003)
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  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]