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Diablo Homolog (DIABLO)

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SMAC; DIABLO-S; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase

Diablo Homolog (DIABLO)
CCC J266
HGNC 21528
MGI 1913843
PubMed 21722859
RGD 1310885
UniProt Q9NR28
DIABLO encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
The predicted SMAC polypeptide contains 239 amino acids. Northern blot analysis detected a 1.5-kb SMAC transcript in all tissues tested, with highest expression in adult testis, high expression in heart, liver, kidney, spleen, prostate, and ovary, and low expression in brain, lung, thymus, and peripheral blood leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ266Hu01 Recombinant Diablo Homolog (DIABLO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ266Hu21 Monoclonal Antibody to Diablo Homolog (DIABLO) WB; IHC; ICC; IP.
PAJ266Hu01 Polyclonal Antibody to Diablo Homolog (DIABLO) WB; IHC; ICC; IP.
Assay Kits SEJ266Hu ELISA Kit for Diablo Homolog (DIABLO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diablo Homolog (DIABLO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diablo Homolog (DIABLO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diablo Homolog (DIABLO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diablo Homolog (DIABLO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diablo Homolog (DIABLO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ266Ra01 Recombinant Diablo Homolog (DIABLO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ266Ra01 Polyclonal Antibody to Diablo Homolog (DIABLO) WB; IHC; ICC; IP.
MAJ266Ra21 Monoclonal Antibody to Diablo Homolog (DIABLO) WB; IHC; ICC; IP.
Assay Kits SEJ266Ra ELISA Kit for Diablo Homolog (DIABLO) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition."Cell 102:33-42(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway."J. Biol. Chem. 275:36152-36157(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein."J. Biol. Chem. 278:52660-52672(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway."Cell Death Differ. 13:2079-2088(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Survivin monomer plays an essential role in apoptosis regulation."J. Biol. Chem. 286:23296-23307(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Structural and biochemical basis of apoptotic activation by Smac/DIABLO."Nature 406:855-862(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain."Nature 408:1004-1008(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64."Am. J. Hum. Genet. 89:56-66(2011) [PubMed] [Europe PMC] [Abstract]