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Density Regulated Protein (DENR)

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DRP; DRP1; SMAP-3; Smooth muscle cell-associated protein 3

Density Regulated Protein (DENR)
CCC J274
HGNC 2769
MGI 1915434
PubMed 17878526
RGD 1589977
UniProt O43583
DENR encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants.
The DRP cDNA predicts a 243-amino acid peptide with consensus sites for N-myristoylation, cAMP- and/or cGMP-dependent protein kinase phosphorylation, and protein kinase C phosphorylation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Density Regulated Protein (DENR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Density Regulated Protein (DENR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Density Regulated Protein (DENR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Density Regulated Protein (DENR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Density Regulated Protein (DENR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Density Regulated Protein (DENR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Density Regulated Protein (DENR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Density Regulated Protein (DENR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Density Regulated Protein (DENR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Density Regulated Protein (DENR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Density Regulated Protein (DENR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Density Regulated Protein (DENR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Density Regulated Protein (DENR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Density Regulated Protein (DENR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Density Regulated Protein (DENR) ELISA Kit Customized Service Offer
  1. "Drp, a novel protein expressed at high cell density but not during growth arrest."DNA Cell Biol. 17:437-447(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells."Nucleic Acids Res. 27:4008-4017(1999) [PubMed] [Europe PMC] [Abstract]
  5. "MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles."Cancer Res. 66:8994-9001(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1."Cancer Genomics Proteomics 4:233-239(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."Genes Dev. 24:1787-1801(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]