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Deformed Epidermal Autoregulatory Factor 1 (DEAF1)

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NUDR; SPN; ZMYND5; Suppressin; Nuclear DEAF-1-related transcriptional regulator; Zinc finger MYND domain-containing protein 5

Deformed Epidermal Autoregulatory Factor 1 (DEAF1)
CCC J278
HGNC 14677
MGI 1858496
PubMed 19668219
RGD 620671
UniProt O75398
Wiki DEAF1
Suppressin is a 63-kD inhibitor of cell proliferation. LeBoeuf et al. (1998) cloned the cDNA encoding rat suppressin. The deduced amino acid sequence contains 2 domains with significant homology to a transcription factor in Drosophila called 'deformed epidermal autoregulatory factor-1' (DEAF1). By RT-PCR, Le Boeuf et al. (1998) found that suppressin was expressed in all rat tissues tested.LeBoeuf et al. (1998) also cloned the human suppressin cDNA sequence, which encodes a predicted 497-amino acid polypeptide.
Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deformed Epidermal Autoregulatory Factor 1 (DEAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deformed Epidermal Autoregulatory Factor 1 (DEAF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deformed Epidermal Autoregulatory Factor 1 (DEAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deformed Epidermal Autoregulatory Factor 1 (DEAF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deformed Epidermal Autoregulatory Factor 1 (DEAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deformed Epidermal Autoregulatory Factor 1 (DEAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deformed Epidermal Autoregulatory Factor 1 (DEAF1) ELISA Kit Customized Service Offer
  1. "Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein."Mol. Endocrinol. 12:1619-1639(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Altered subcellular localization of suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas."Clin. Cancer Res. 7:3495-3503(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes."Nat. Immunol. 10:1026-1033(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Nuclear DEAF-1-related (NUDR) protein contains a novel DNA binding domain and represses transcription of the heterogeneous nuclear ribonucleoprotein A2/B1 promoter."J. Biol. Chem. 274:30510-30519(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation."Nat. Struct. Biol. 8:626-633(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland."BMC Dev. Biol. 8:94-94(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex."PLoS ONE 7:E33404-E33404(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations affecting the SAND domain of DEAF1 cause intellectual disability with severe speech impairment and behavioral problems." Am. J. Hum. Genet. 94:649-661(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Structure and functional analysis of the MYND domain."J. Mol. Biol. 358:498-508(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Retraction notice to 'Structure and functional analysis of the MYND domain' [J. Mol. Biol. (2006) 358, 498-508]."J. Mol. Biol. 376:1523-1523(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Structural and functional analysis of the DEAF-1 and BS69 MYND domains."PLoS ONE 8:E54715-E54715(2013) [PubMed] [Europe PMC] [Abstract]
  15. "A de novo paradigm for mental retardation."Nat. Genet. 42:1109-1112(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Novel homozygous DEAF1 variant suspected in causing white matter disease, intellectual disability, and microcephaly."Am. J. Med. Genet. A 164A:1565-1570(2014) [PubMed] [Europe PMC] [Abstract]