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DNA Damage Inducible Transcript 4 (DDIT4)

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Dig2; REDD-1; REDD1; RTP801; HIF-1 Responsive RTP801; Protein regulated in development and DNA damage response 1

DNA Damage Inducible Transcript 4 (DDIT4)
CCC J281
HGNC 24944
MGI 1921997
PubMed 24191950
RGD 621731
UniProt Q9NX09
Wiki DDIT4
The 232-amino acid human protein has a calculated molecular mass of 25 kD and shares 90% amino acid conservation with the rat protein. In an in vitro translation assay, both rat and human RTP801 cDNAs gave rise to 35-kD proteins. Northern blot analysis of human tissues detected low-level ubiquitous expression of a 1.8-kb transcript. Lowest expression was in brain, skeletal muscle, and intestine.
The predicted human REDD1 protein is acidic and rich in serine. It has orthologs in mouse, Xenopus, and Drosophila, with strongest evolutionarily sequence conservation at the C terminus. A related human transcript encodes a protein with 50% overall identity to REDD1, which the authors termed REDD2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Inducible Transcript 4 (DDIT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Inducible Transcript 4 (DDIT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Inducible Transcript 4 (DDIT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Inducible Transcript 4 (DDIT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Inducible Transcript 4 (DDIT4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Inducible Transcript 4 (DDIT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Inducible Transcript 4 (DDIT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Inducible Transcript 4 (DDIT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Inducible Transcript 4 (DDIT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Inducible Transcript 4 (DDIT4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Inducible Transcript 4 (DDIT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Inducible Transcript 4 (DDIT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Inducible Transcript 4 (DDIT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Inducible Transcript 4 (DDIT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Inducible Transcript 4 (DDIT4) ELISA Kit Customized Service Offer
  1. "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species."Mol. Cell 10:995-1005(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis."Mol. Cell. Biol. 22:2283-2293(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity."Exp. Mol. Med. 35:403-411(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex."Genes Dev. 18:2893-2904(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfonate through CCAAT/enhancer binding protein."Biochemistry 44:3909-3914(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway."J. Biol. Chem. 280:9769-9772(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of mTOR and cell growth in response to energy stress by REDD1."Mol. Cell. Biol. 25:5834-5845(2005) [PubMed] [Europe PMC] [Abstract]
  12. "REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase."Oncogene 24:1138-1149(2005) [PubMed] [Europe PMC] [Abstract]
  13. "RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation."J. Neurosci. 26:9996-10005(2006) [PubMed] [Europe PMC] [Abstract]
  14. "RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation."Exp. Hematol. 35:572-578(2007) [PubMed] [Europe PMC] [Abstract]
  15. "REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase."EMBO Rep. 10:866-872(2009) [PubMed] [Europe PMC] [Abstract]
  16. "TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1."Oncogene 30:3792-3801(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Structural analysis and functional implications of the negative mTORC1 regulator REDD1."Biochemistry 49:2491-2501(2010) [PubMed] [Europe PMC] [Abstract]