≡

Carbohydrate Sulfotransferase 14 (CHST14)

[Edit]

D4ST1; HNK1ST; D4ST-1; HD4ST; Dermatan 4 Sulfotransferase 1

Carbohydrate Sulfotransferase 14 (CHST14)
CCC J300
HGNC 24464
MGI 1919386
PubMed 20533528
RGD 1585023
UniProt Q8NCH0
Wiki CHST14
D4ST1 catalyzes the 4-O-sulfation of N-acetylgalactosamine (GalNAc) residues in dermatan sulfate, a stereoisomeric form of chondroitin sulfate that contains varying proportions of iduronic acid in place of glucuronic acid .
The deduced 376-amino acid protein has a calculated molecular mass of 43 kD. D4ST1 is a type II membrane protein with an N-terminal transmembrane region, binding sites for 3-prime-phosphoadenosine-5-prime-phosphosulfonate (PAPS), and 2 potential N-glycosylation sites. D4ST1 shares significant similarity with other sulfotransferases. The N-terminal regions are most variable. Northern blot analysis detected a 2.4-kb transcript in heart, placenta, liver, and pancreas, with significantly lower levels in skeletal muscle and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 14 (CHST14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 14 (CHST14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 14 (CHST14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 14 (CHST14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 14 (CHST14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 14 (CHST14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 14 (CHST14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 14 (CHST14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 14 (CHST14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 14 (CHST14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 14 (CHST14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 14 (CHST14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 14 (CHST14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 14 (CHST14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 14 (CHST14) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase."J. Biol. Chem. 276:36344-36353(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis."J. Biol. Chem. 278:36115-36127(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate."Glycobiology 19:1197-1203(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Musculocontractural Ehlers-Danlos syndrome (former EDS type VIB) and adducted thumb clubfoot syndrome (ATCS) represent a single clinical entity caused by mutations in the dermatan-4-sulfotransferase 1 encoding CHST14 gene."Hum. Mutat. 31:1233-1239(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Loss of dermatan-4-sulfotransferase 1 function results in adducted thumb-clubfoot syndrome."Am. J. Hum. Genet. 85:873-882(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome." Hum. Mutat. 31:966-974(2010) [PubMed] [Europe PMC] [Abstract]