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Cancer/Testis Antigen 1A (CTAG1A)

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LAGE2A; ESO1; CTAG; CTAG1; LAGE2; Autoimmunogenic cancer/testis antigen NY-ESO-1; L antigen family member 2

Cancer/Testis Antigen 1A (CTAG1A)
CCC J315
HGNC 24198
PubMed 20208059
UniProt P78358
CTAG1A is an identical copy of the CTAG1B gene. By SEREX (serologic analysis of recombinant cDNA expression libraries) of an esophageal carcinoma cDNA library using autologous patient serum, Chen et al. (1997) identified a clone corresponding to the CTAG (cancer/testis antigen) gene, which they designated NYESO1.
Aradhya et al. (2001) identified CTAG1A, which they called LAGE2A, within a duplicated region of chromosome X associated with incontinentia pigmenti. Sequence analysis showed that the CTAG1A gene is 100% identical to the CTAG1B gene.By sequencing BAC and PAC clones, Aradhya et al. (2001) mapped the CTAG1A gene to chromosome Xq28. It lies in the opposite orientation and centromeric to the CTAG1B gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cancer/Testis Antigen 1A (CTAG1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cancer/Testis Antigen 1A (CTAG1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cancer/Testis Antigen 1A (CTAG1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cancer/Testis Antigen 1A (CTAG1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cancer/Testis Antigen 1A (CTAG1A) ELISA Kit Customized Service Offer
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  2. "LAGE-1, a new gene with tumor specificity."Int. J. Cancer 76:903-908(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames."J. Immunol. 161:3598-3606(1998) [PubMed] [Europe PMC] [Abstract]
  4. "DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter."Mol. Cell. Biol. 19:7327-7335(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes."Hum. Mol. Genet. 10:2557-2567(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ."Lab. Invest. 82:775-780(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Structural and kinetic basis for heightened immunogenicity of T cell vaccines."J. Exp. Med. 201:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]