Cancer/Testis Antigen 1B (CTAG1B)

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CTAG; CTAG1; ESO1; LAGE-2; LAGE2B; NY-ESO-1; CAMEL; ESO2; LAGE-1; LAGE-2b; LAGE2A; Autoimmunogenic cancer/testis antigen NY-ESO-1; L antigen family member 2

Cancer/Testis Antigen 1B (CTAG1B)
Cancer/testis antigens, such as CTAG1B, are expressed in a variety of malignant tumors but soley in testis among normal adult tissues.
NYESO1 expression in primary MTC tissues significantly correlated with tumor recurrence. The presence of specific anti-NYESO1 antibodies was searched in the sera of MTC-affected patients examined by ELISA using recombinant NYESO1 protein. A humoral response against this CTA was detected in 6 of 11 NYESO1-expressing patients (54.5%), and in 1 of 6 patients with an NYESO1-negative tumor. Anti-NYESO1 antibodies were present in 15 of 42 sera (35.7%), demonstrating that MTC is a neoplasm frequently associated with humoral immune response to NYESO1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ316Hu01 Recombinant Cancer/Testis Antigen 1B (CTAG1B) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ316Hu02 Recombinant Cancer/Testis Antigen 1B (CTAG1B) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ316Hu03 Recombinant Cancer/Testis Antigen 1B (CTAG1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ316Hu21 Monoclonal Antibody to Cancer/Testis Antigen 1B (CTAG1B) WB; IHC; ICC; IP.
PAJ316Hu01 Polyclonal Antibody to Cancer/Testis Antigen 1B (CTAG1B) WB; IHC; ICC; IP.
PAJ316Hu02 Polyclonal Antibody to Cancer/Testis Antigen 1B (CTAG1B) WB; IHC; ICC; IP.
Assay Kits SEJ316Hu ELISA Kit for Cancer/Testis Antigen 1B (CTAG1B) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening."Proc. Natl. Acad. Sci. U.S.A. 94:1914-1918(1997) [PubMed] [Europe PMC] [Abstract]
  2. "LAGE-1, a new gene with tumor specificity."Int. J. Cancer 76:903-908(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames."J. Immunol. 161:3598-3606(1998) [PubMed] [Europe PMC] [Abstract]
  4. "DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter."Mol. Cell. Biol. 19:7327-7335(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes."Hum. Mol. Genet. 10:2557-2567(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ."Lab. Invest. 82:775-780(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Structural and kinetic basis for heightened immunogenicity of T cell vaccines."J. Exp. Med. 201:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]