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Cancer/Testis Antigen 2 (CTAG2)

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LAGE-1; CAMEL; LAGE1; ESO2; CT6.2a; CT6.2b; LAGE-1a; LAGE-1b; Autoimmunogenic cancer/testis antigen NY-ESO-2; L antigen family member 1

Cancer/Testis Antigen 2 (CTAG2)
CCC J317
HGNC 2492
PubMed 23390371
UniProt O75638
CTAG2 encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID 10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants.
One transcript predicts a 180-amino acid protein of 18.2 kD and the second is an unspliced variant that predicts a 210-amino acid protein of 21.1 kD. The third transcript, which they designated CAMEL, predicts a 109-amino acid protein with a molecular mass of 11.7 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cancer/Testis Antigen 2 (CTAG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cancer/Testis Antigen 2 (CTAG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cancer/Testis Antigen 2 (CTAG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cancer/Testis Antigen 2 (CTAG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cancer/Testis Antigen 2 (CTAG2) ELISA Kit Customized Service Offer
  1. "LAGE-1, a new gene with tumor specificity."Int. J. Cancer 76:903-908(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1."Int. J. Cancer 82:442-448(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes."Hum. Mol. Genet. 10:2557-2567(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients."J. Cancer Res. Clin. Oncol. 134:495-502(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]