CSTF3 is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
Northern blot analysis of several human tissues detected a 3.2-kb transcript predominantly in lung. In mouse, Cstf3 expression was strong during embryonic development beginning at embryonic day 11 and much weaker in adult tissues.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Cleavage Stimulation Factor 3 (CSTF3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Cleavage Stimulation Factor 3 (CSTF3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Cleavage Stimulation Factor 3 (CSTF3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Cleavage Stimulation Factor 3 (CSTF3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cleavage Stimulation Factor 3 (CSTF3) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Cleavage Stimulation Factor 3 (CSTF3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Cleavage Stimulation Factor 3 (CSTF3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Cleavage Stimulation Factor 3 (CSTF3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Cleavage Stimulation Factor 3 (CSTF3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cleavage Stimulation Factor 3 (CSTF3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Cleavage Stimulation Factor 3 (CSTF3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Cleavage Stimulation Factor 3 (CSTF3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Cleavage Stimulation Factor 3 (CSTF3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Cleavage Stimulation Factor 3 (CSTF3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cleavage Stimulation Factor 3 (CSTF3) | ELISA Kit Customized Service Offer |
- "A subunit of the polyadenylation factor CstF is the human homologue of the Drosophila suppressor of forked protein."Nature 372:471-474(1994) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Complex protein interactions within the human polyadenylation machinery identify a novel component."Mol. Cell. Biol. 20:1515-1525(2000) [PubMed] [Europe PMC] [Abstract]
- "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase."EMBO J. 23:616-626(2004) [PubMed] [Europe PMC] [Abstract]
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
- "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
- "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]